Metabolic pathway of AA transformation into eicosanoid products. Once a cell is activated by a proinflammatory stimulus that engages a Gαq-coupled seven-transmembrane receptor, AA can be cleaved by cytosolic PLA2 from phospholipids that compose cellular membranes (mostly nuclear, endoplasmic reticulum or Golgi membranes). Free AA can subsequently be converted into different eicosanoid products by different enzymes (represented in blue), notably the COX and LO pathways. This review will mainly focus on the prostanoids - PGE2, and 15d-PGJ2 prostaglandins - and on 5-LO products, namely LTs. Only eicosanoids and pathways of interest in this paper are depicted.