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Table 1 principal characteristics of the main HLA-C variants

From: HLA-C and HIV-1: friends or foes?

HLA-C allele

miR418a site/expression[32, 34–36, 52, 53, 59]

−35 kb SNP[32]

Val/Met 304[57, 59]

KIR group type[74, 75]

CTL restriction

Association with control

Association with progression

Increase of HIV-1 infectivity[92, 93]

01.02

Intact/Low

C

Val*

C1

[69]

  

NT

02.02

Deleted/High

C

Val*

C2

 

[53]

 

NT

03.03, .04

Intact/Low

T

Val*

C1

[63, 66]

  

Yes

04.01

Intact/Low

T

Val*

C2

[63–68]

 

[34, 37]

Yes

05.01

Deleted/High

C

Met*/Val*

C2

   

NT

06.02

Deleted/High

C

Met*/Val*

C2

   

NT

07.01, .02, .04

Intact/Low

T

Val

C1

[63, 70]

 

[36]

Yes

08.01, .02, .04

Deleted/High

C

Met*/Val*

C1

   

NT

12.02, .03

Deleted/High

C

Met*/Val*

C1*

[54]

[54]

 

Yes ?**

14.02

Intact/Low

C

Val*

C1*

   

NT

15.02, .05, .06

Deleted/High

T

Met*/Val*

C2*

[63]

  

NT

16.01, .02, .04

Deleted/High

T

Val*

C1*

   

NT

17.01

Intact/Low

T

Val*

C2*

   

NT

  1. *: data obtained by sequence alignment analysis.
  2. **: C*12/C*07.
  3. NT not tested.
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Retrovirology

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