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Table 2 Prevalence of observed mutations in HIV-1 sequences

From: MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

   HIV-1 subtype CRF
Amino Acid Position All A B C 01_AE 02_AG
105 H wt 83 90 87 97 6 98
  Y mutant ~ 0a 0 0 ~ 0 0 0
255 V wt 96 92 97 98 98 96
  M mutant 0 0 0 0 0 0
335 G wt 21 10 14 13 81 11
  R mutant 32 55 46 17 6 39
375 S wt 78 91 79 92 1 93
  R mutant ~ 0 ~ 0 ~ 0 ~ 0 0 0
  N mutant 2 0 3 8 0 0
471 G wt 78 87 80 80 84 91
  R mutant ~ 0 0 ~ 0 0 1 0
  E mutant 4 3 3 6 8 5
474 D wt 62 78 68 55 8 95
  N mutant 36 22 31 44 92 5
494 L wt 92 92 93 99 99 83
  V mutant 1 1 2 ~ 0 0 1
  1. Prevalence (in percentage) of certain amino acids for the most prevalent HIV-1 subtypes at positions mutated in the resistant viruses is given. All: 3045 HIV-1/SIV Env sequences (Los Alamos National Lab data bank 2011); A, B and C correspond to HIV-1 subtypes. Number of Env sequences: subtype A = 186; subtype B = 1001; subtype C = 756; CRF01_AE = 186; CRF02_AG = 100. a ~ 0 means less than 0.3%.