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Table 2 Prevalence of observed mutations in HIV-1 sequences

From: MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

  

HIV-1 subtype

CRF

Amino Acid Position

All

A

B

C

01_AE

02_AG

105

H

wt

83

90

87

97

6

98

 

Y

mutant

~ 0a

0

0

~ 0

0

0

255

V

wt

96

92

97

98

98

96

 

M

mutant

0

0

0

0

0

0

335

G

wt

21

10

14

13

81

11

 

R

mutant

32

55

46

17

6

39

375

S

wt

78

91

79

92

1

93

 

R

mutant

~ 0

~ 0

~ 0

~ 0

0

0

 

N

mutant

2

0

3

8

0

0

471

G

wt

78

87

80

80

84

91

 

R

mutant

~ 0

0

~ 0

0

1

0

 

E

mutant

4

3

3

6

8

5

474

D

wt

62

78

68

55

8

95

 

N

mutant

36

22

31

44

92

5

494

L

wt

92

92

93

99

99

83

 

V

mutant

1

1

2

~ 0

0

1

  1. Prevalence (in percentage) of certain amino acids for the most prevalent HIV-1 subtypes at positions mutated in the resistant viruses is given. All: 3045 HIV-1/SIV Env sequences (Los Alamos National Lab data bank 2011); A, B and C correspond to HIV-1 subtypes. Number of Env sequences: subtype A = 186; subtype B = 1001; subtype C = 756; CRF01_AE = 186; CRF02_AG = 100. a ~ 0 means less than 0.3%.
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Retrovirology

ISSN: 1742-4690

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