Figure 1

Locations of gp120 mutations associated with resistance towards miniCD4 proteins M48 and M48U1. Overall view of gp120 (grey), and M48 (blue). Based on the previously published structures of YU2 core gp120 and Fab 17b in complex with sCD4 or with M48 miniCD4, all the native residues (His105, Val255, Gly335, Ser375, Gly471, Asp474 and Leu494) that are present in BaL or SF162 envelope and were mutated during the resistance induced by M48 and/or M48U1 are represented in yellow and in ball formats. The Phenylalanine at position 23 of M48 is highlighted in red and in stick representation. This drawing was made using PyMOL with coordinates that can be found at pdb accession codes [PDB:2I60] and [PDB:3JWD].