Figure 8
From: Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication
Effect of exogenous CypA expression on SIV and HIV-1 replication. (A) The amounts of viral cDNA synthesized after SIVagm (left panel) or HIV-1 (right panel) infection in human CEM-SS cells. Viruses produced from normal CEM-SS cells were used to infect CsA-untreated or CsA-treated target normal CEM-SS cells. Heat-inactivated virus was used as an infection control. Relative viral cDNA levels are shown as the ratio (%) of the viral cDNA levels to that of viruses produced from CsA-untreated CEM-SS in CsA-untreated CEM-SS cells. Mean values and standard deviations in three independent experiments are shown. (B) The amounts of viral cDNA after SIVagm infection in macaque HSC-F cells. SIVagm produced from normal HSC-F cells was used to infect CsA-untreated or CsA-treated target normal HSC-F cells. Heat-inactivated virus was used as an infection control. Relative viral cDNA levels are shown as the ratio (%) of the viral cDNA levels to that of viruses produced from CsA-untreated HSC-F in CsA-untreated HSC-F cells. Mean values and standard deviations in three independent experiments are shown.