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Table 1 Randomization schemes used to introduce variability at specific positions of ankyrin repeats (a)

From: Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein

Repeat position

Degenerated codons

Subset of encoded amino acid

2

VDK, DMY, RAA

A, D, E, G, H, I, K, L, M, N, Q, R, S, T, V, Y

3

VDK, DMY, VAN

A, D, E, G, H, I, K, L, M, N, Q, R, S, T, V, Y

5

VDK, DMY, VAN, TGG

A, D, E, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y

10

CTG, TGG, TAC, RTC

I, L, V, W, Y

13

KCK, TAC, CGY, VAR

A, E, F, I, K, L, M, Q, R, S, Y

14

KCK, VAR, AAC, SGY, YAY, NTG

A, E, G, H, K, L, M, N, Q, R, S, V, Y

  1. (a) For each position indicated on the leftmost column, the degenerated codons used for the microgene synthesis and the corresponding encoded amino-acids are indicated in the middle and rightmost columns, respectively. Standard letter for mixed bases refer to: N = A/T/G/C, V = A/C/G, D = A/G/T, K = G/T, M = A/C, Y = C/T, R = A/G.
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Retrovirology

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