Figure 6

Minocycline downregulated HLA-ABC expressions in CD14⁺ cells of patients with HAM/TSP. (A) Representative histograms of HLA-ABC expression on CD14⁺ cells of a HAM/TSP patient. Staining on CD14⁺ cells before culture (closed histogram) and after culture for 5 hours and 18 hours, with minocycline (grayed histogram) and without minocycline (opened histogram), were shown. (B) Comparison of HLA-ABC expression in CD14⁺ cells of HAM/TSP patients after 18 hours culture with minocycline (closed circle) or without minocycline (opened circle). The mean fluorescent intensities of MHC class I expression on CD14⁺ cells were significantly inhibited by treatment with minocycline at 18 hours culture (*p = 0.0382). Error bars represent SD.