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Figure 2 | Retrovirology

Figure 2

From: WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

Figure 2

Importance of Wip1 in modulating an oscillatory negative feedback loop within the p53 response pathway. Tax-induced DNA damage initiates a cascade that stimulates p53 expression. p53 then upregulates Wip1 creating a negative feedback loop. If DNA damage has not been completely repaired during the first pulse, the cycle repeats with a lower intensity. This mechanism generates a series of p53 and Wip1 pulses in an oscillating pattern that attenuates until the DNA damage is repaired.

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