Importance of Wip1 in modulating an oscillatory negative feedback loop within the p53 response pathway. Tax-induced DNA damage initiates a cascade that stimulates p53 expression. p53 then upregulates Wip1 creating a negative feedback loop. If DNA damage has not been completely repaired during the first pulse, the cycle repeats with a lower intensity. This mechanism generates a series of p53 and Wip1 pulses in an oscillating pattern that attenuates until the DNA damage is repaired.