Figure 10
From: HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency
Modified chromosome projection mandalas depicting NANOG, OCT4, SOX2 and KLF4 associations with HERV-H proviruses. Mandalas were generated as described in reference [18] and Figure 4 above. The green ring indicates the HERV-H 5′ LTR region (500 nucleotides from the transcriptional start site). Dot size is proportional to the expression level of each single provirus. NANOG is bound to the 5′LTR of almost all highly expressed retroviruses. OCT4 shows a significant association. SOX2 binds all expressed HERV-H in a region between 1 KB and 2 KB while KLF4 does not show any significant association pattern.