A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Table 2 Inhibitory activity of the recombinant proteins and peptides on HIV-1-mediated cell-cell fusion and HIV-1 replication

Concentration (nM)	D1D2		2DLT		T20		T1144
Concentration (nM)	IC₅₀	IC₉₀	IC₅₀	IC₉₀	IC₅₀	IC₉₀	IC₅₀	IC₉₀
HIV-1 IIIB-mediated cell fusion
	97.83	137.18	19.03	46.51	20.15	41.71	5.89	15.26
HIV-1 replication
IIIB (B, X4)	56.80	246.02	5.64	28.79	17.26	117.21	2.13	35.23
Bal (B, R5)	170.20	>250	10.78	44.35	43.35	>250	4.03	28.11
92US657 (B, R5)*	>250	>250	17.17	51.85	56.07	223.92	13.21	42.26
93 MW959 (C, R5)*	>250	>250	18.93	48.86	4.70	18.76	2.35	16.25
92TH009 (E/A, R5)*	25.30	113.69	17.50	71.93	1.43	7.99	1.36	6.21

ISSN: 1742-4690