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Table 2 Inhibitory activity of the recombinant proteins and peptides on HIV-1-mediated cell-cell fusion and HIV-1 replication

From: A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Concentration (nM) D1D2 2DLT T20 T1144
IC50 IC90 IC50 IC90 IC50 IC90 IC50 IC90
HIV-1 IIIB-mediated cell fusion
  97.83 137.18 19.03 46.51 20.15 41.71 5.89 15.26
HIV-1 replication
IIIB (B, X4) 56.80 246.02 5.64 28.79 17.26 117.21 2.13 35.23
Bal (B, R5) 170.20 >250 10.78 44.35 43.35 >250 4.03 28.11
92US657 (B, R5)* >250 >250 17.17 51.85 56.07 223.92 13.21 42.26
93 MW959 (C, R5)* >250 >250 18.93 48.86 4.70 18.76 2.35 16.25
92TH009 (E/A, R5)* 25.30 113.69 17.50 71.93 1.43 7.99 1.36 6.21
  1. *Primary HIV-1 isolates.