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Figure 7 | Retrovirology

Figure 7

From: A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Figure 7

The putative mechanisms of action of 2DLT to inactivate virions and to inhibit viral fusion and entry. 2DLT binds to gp120 via its D1D2 domain and induces the exposure of the grooves of the gp41 trimer, which subsequently binds the T1144 domain in 2DLT, leading to irreversible inactivation of HIV-1 (model a). Like T1144, 2DLT may also directly bind to gp41 NHR via the T1144 domain to inhibit HIV-1 fusion with the target cell (model b).

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