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Figure 3 | Retrovirology

Figure 3

From: The role of G protein gene GNB3 C825TPolymorphism in HIV-1 acquisition, progression and immune activation

Figure 3

Expression of ex vivo cell surface markers measured by flow cytometry among HIV-1-negative subjects. (A) Expression of CD69, HLA-DR, CD38 and regulatory T cells (Tregs; defined as CD3+CD4+CD25+FOXP3+) among HIV-1-negative CSW cohort subjects. Values are expressed as a percentage of the parental CD4+ or CD8+ T cell population, as indicated. CD38 and HLA-DR plots are representative of two distinct studies. There were no significant differences in expression levels between GNB3 825CC/CT and 825TT groups as measured by Mann-Whitney test [p > 0.1 for all]. (B) Expression of HIV-1 co-receptors CCR5 and CXCR4 expressed as a percentage of the parental CD4+ T cell population. There were no significant differences in expression levels or CCR5 median fluorescence intensity (MFI) between GNB3 825CC/CT and 825TT groups as measured by Mann-Whitney test [p > 0.1 for all]. (C) Expression of activation markers CD69 and HLA DR on CD4+CCR5+ T cells. There were no significant differences in expression levels between GNB3 825CC/CT and 825TT groups as measured by Mann-Whitney test [p > 0.1 for all].

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