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Figure 3 | Retrovirology

Figure 3

From: Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

Figure 3

HIV-1 CA mutants that confer TNPO3-independence localize to the interface between two monomers in the hexameric CA lattice. (A) Absolute infectivity relative to WT virus of TNPO3-independent CA mutants. Data represent one of at least three independent experiments. Error bars represent ± SEM (n = 3). (B) Location of CA amino acid residues important for TNPO3-dependence of HIV-1. Space-fill model of a CA dimer extracted from the hexameric structure (PDB: 3H4E). The location of mutants with absolute infectivity similar WT is indicated in magenta. The location of mutants with an absolute infectivity defect are shown in blue; Q63 is in the dimer interface and not visible in this view.

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Retrovirology

ISSN: 1742-4690

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