CD8+ T cell functional analysis. The effect of CD8+ T cell depletion on autologous virus outgrowth is shown by a comparison of virus replication in activated unfractionated PBMC or activated PBMC from which CD8+ T cells were depleted (A). The ability of CD8+ T cells to inhibit replication of GFP expression virus in activated autologous CD4+ T cells is shown. Open bars were below the limit of the detection. (B) by comparing the percentage of infected CD4+ T cells (GFP positive) in the absence and presence of CD8+ T cells.