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Table 1 Optimised parameters from the mathematical model describing the proportion of MDTF cells expressing EYFP that also expressed EGFP

From: Binding of more than one Tva800 molecule is required for ASLV-A entry

System

Number of receptors needed for viral entry

k

Model error

D

Efficiency of delivery vector

p

Number of receptors produced for each TVA integration r

Receptor efficiency q

Relative rate at which bound viruses acquire more receptors γ

Tva950

1

0.0258

1

1.579

0.198

n/a

Tva800

1

0.106

0.25

0.921

1

n/a

Tva800

1

0.176

1*

0.925

0.300

n/a

Tva800

2

0.120

1

0.979

0.992

9.837

Tva800

3

0.165

1

0.990

1

159.3

  1. In each case the number of receptors needed for viral entry was fixed, while other parameters were optimised to maximise the fit to the experimental data. A calculation for Tva800 with one receptor needed for viral entry was rerun, with the efficiency of the delivery vector fixed to match that obtained for Tva950. The error D gives the RMSD difference between the model and the experimental data in each case. Efficiencies are expressed as probabilities, such that an efficiency of 1 is equivalent to 100%.
  2. *parameter fixed, not optimised
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Retrovirology

ISSN: 1742-4690

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