Figure 7

HERC5 and ISG15 expression in HIV-1-infected patients. The Gene Expression Omnibus database repository was searched to identify published transcriptional profiling datasets of HIV-1- infected patient samples. The average relative RNA expression levels of HERC5, ISG15 and beta actin were compared for each dataset. A, GSE16363 dataset from Li et al. (2009) comparing patients with asymptomatic and acute stages of AIDS and patients with AIDS. B, GDS2168 dataset from Tilton et al. (2006) comparing monocytes from viremic individuals after cessation of HAART and aviremic patients during HAART. C, GDS1449 dataset from Ockenhouse et al. (2005) comparing primary human PBMCs from seropositive patients compared to seronegative patients. D, GDS2649 dataset from Hyrcza et al. (2007) comparing CD4+ T cells from non-progressors, and acutely and chronically infected patients. E, GSE23879 dataset from Vigneault et al. (2011) comparing elite controllers and patients treated with HAART. Significance was calculated using Student's unpaired t test. P values < 0.05 were considered significant.