Figure 1
From: An autoimmune disease prevented by anti-retroviral drugs
Effect of reverse transcriptase inhibitors on survival of Trex1-deficient mice. A) Inhibition of MLV cDNA synthesis by Truvada/Viramune. Flow cytometry graphs displaying GFP intensity generated by provirus: y-axis, cell number; x-axis, fluorescence intensity on a logarithmic scale. An MLV-based vector encoding GFP was added to NIH/3T3 cell cultures with 0, 100 nM, or 1 μM. B) Survival curves showing the effect of Truvada/Viramune (+ drug; magenta circles) on Trex1-deficient mice [13] obtained from D. Stetson [9]. The drugs were given from conception via the drinking water as a solution of 3 × 10-4 M nevirapine, 1.6 × 10-4 M emtricitabine and 9.4 × 10-5 M tenofovir. Log rank test for the drug effect, p = 0.000014. C) Hematoxylin-eosin stained sections of the left heart ventricle of treated (+ drug) and non-treated (- drug) mice killed at 9 and 7 months of age, respectively. Sections from three mice were examined in each category.