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Table 1 Full-length and near full-length HML-2 proviruses

From: Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

Locus Alias Chr Orientation Start End Oldest
Common
Ancestora
Estimated
Agef
Polymorphic
Alleles
ORFs References
1p36.21b K(OLDAL023753),
K6,
K76
1 (+) 13458305 13467826 Orangutan 22.47-40.68   gag Reus et al.,
2001
1p31.1 K4, K116, ERVK-
1
1 (+) 75842771 75849143 Human
Specific
< 2 Provirus gag Hughes and
Coffin, 2001
1q21.3   1 (-) 150605284 150608361 Orangutan N/A    This Study
1q22 K102, K(C1b),
K50a, ERVK-7
1 (-) 155596457 155605636 Human
Specific
< 2    Barbulescu et
al., 1999
1q23.3 K110, K18,
K(C1a), ERVK-18
1 (+) 160660575 160669806 Gorillab 7.81-14.14    Barbulescu et
al., 199
1q24.1 K12 1 (-) 166574603 166580258 Rhesus 14.17-25.65    Romano et al.,
2006
1q32.2   1 (-) 207808457 207812636 Orangutan N/A    This Study
2q21.1   2 (-) 130719538 130722209 Human
Specific
N/A    This Study
3p25.3 K11, ERVK-2 3 (-) 9889346 9896236 Orangutan 12.13-21.96*    Hughes and
Coffin, 2001
3p12.3   3 (+) 75600465 75609150 Chimpanzee N/A    This Study
3q12.3 K(II), ERVK-5 3 (+) 101410737 101419859 Gorillab 5.51-9.98    Sugimoto et al.,
2001
3q13.2 K106, K(C3),
K68, ERVK-3
3 (-) 112743479 112752282 Human
Specific
< 2 Provirus,
soloLTR
gag Barbulescu et
al., 1999
3q21.2 K(I), ERVK-4 3 (+) 125609302 125618416 Human
Specific
4.8-8.69    Sugimoto et al.,
2001
3q24 ERVK-13 3 (-) 148281477 148285396 Human
Specific
N/A   gag This Study
3q27.2 K50b, K117,
ERVK-11
3 (-) 185280336 185289515 Human
Specific
< 2   gag, pol Hughes and
Coffin, 2001
4p16.3a   4 (+) 234989 239459 Rhesus N/A    This Study
4p16.1a K17b 4 (+) 9123515 9133075 Chimpanzee 16.84-30.49    Romano et al.,
2006
4q13.2   4 (+) 69463709 69469223 Orangutan 17.09-30.95   env This Study
4q32.1   4 (+) 161579938 161582360 Chimpanzee N/A    This Study
4q32.3 K5, ERVK-12 4 (+) 165916840 165924068 Orangutan 9.24-16.73    Hughes and
Coffin, 2001
4q35.2   4 (-) 191027414 191034701 Human
Specific
13.07-23.67    This Study
5p13.3 K104, K50d 5 (-) 30487114 30496205 Human
Specific
6.32-11.44    Barbulescu et
al., 1999
5p12   5 (-) 46000159 46010002 Orangutan 13.39-24.24    This Study
5q33.3 K107/K10,
K(C5), ERVK-10
5 (-) 156084717 156093896 Human
Specific
< 2   gag, pol Ono et al., 1986
6p22.1 K(OLDAL121932),
K69,
K20
6 (+) 28650367 28660735 Orangutan 19.55-35.4    Reus et al.,
2001
6p21.1 K(OLDAL035587),
KOLD35587
6 (-) 42861409 42871367 Rhesus 9.83-17.81    Reus et al.,
2001
6q14.1 K109, K(C6),
ERVK-9
6 (-) 78427019 78436083 Human
Specific
< 2 Provirus,
soloLTR
gag, env Barbulescu et
al., 1999
6q25.1   6 (+) 151180749 151183574 Rhesus N/A   env This Study
7p22.1a K108L, K
(HML.2-HOM),
K(C7), ERVK-6
7 (-) 4622057 4631528 Human
Specific
< 2 Provirus,
Tandem
Repeat,
SoloLTR
pol, env Barbulescu et
al., 1999
7p22.1b K108R, ERVK-6 7 (-) 4630561 4640031 Human
Specific
< 2 Provirus,
Tandem
Repeat,
SoloLTR
pol, env Barbulescu et
al., 1999
7q22.2 ERVK-14 7 (-) 104388369 104393266 Human
Specific
N/A   gag This Study
7q34 K(OLDAC004979),
ERVK-15
7 (-) 141450926 141455903 Orangutan N/A   gag Reus et al.,
2001
8p23.1a K115, ERVK-8 8 (-) 7355397 7364859 Human
Specific
4.87-8.82* Provirus gag, pol, env Turner et al.,
2001
8p23.1b K27 8 (+) 8054700 8055725 Chimpanzee 16.09-29.13    Hughes and
Coffin, 2001
8p23.1c   8 (-) 12073970 12083497 Chimpanzee 15-27.17    Hughes and
Coffin, 2001
8p23.1d KOLD130352 8 (-) 12316492 12326007 Human
Specifice
15.22-27.56    Hughes and
Coffin, 2001
8q11.1 K70, K43 8 (-) 47175650 47183661 Unknownd 23.46-42.48    Romano et al.,
2006
8q24.3a   8 (-) 140472149 140475236 Human
Specific
N/A    This Study
9q34.11 K31 9 (+) 131612515 131619736 Orangutan 12.43-22.51    Hughes and
Coffin, 2001
9q34.3 K30 9 (-) 139674766 139684228 Orangutan 15.46-28    Hughes and
Coffin, 2001
10p14 K(C11a), K33,
ERVK-16
10 (-) 6867109 6874635 Gorillab 7.36-13.32    Costas et al.,
2001
10p12.1 K103, K(C10) 10 (+) 27182399 27183380 Human
Specific
1.61-2.91 Provirus,
SoloLTR
gag, pol Barbulescu et
al., 1999
10q24.2 ERVK-17, c10_B 10 (-) 101580569 101587716 Human
Specific
N/A   gag Macfarlane and
Simmonds,
2004
11p15.4 K7 11 (-) 3468656 3478209 Human
Specifice
15.44-27.95    Romano et al.,
2006
11q12.1   11 (+) 58767448 58773196 Chimpanzee N/A   env This Study
11q12.3 K(OLDAC004127) 11 (-) 62135963 62150563 Gibbonc 19.46-35.24*   pol Reus et al.,
2001
11q22.1 K(C11c), K36,
K118, ERVK-25
11 (+) 101565794 101575259 Human
Specific
< 2 Provirus,
SoloLTR
pol Costas et al.,
2001
11q23.3 K(C11b), K37,
ERVK-20
11 (-) 118591724 118600883 Gorillab 13.35-24.18   gag Costas et al.,
2001
12p11.1 K50e 12 (-) 34772555 34782217 Chimpanzee 39.23-71.02    Romano et al.,
2006
12q13.2   12 (+) 55727215 55728183 Human
Specific
< 2 Provirus,
SoloLTR
gag, pol Belshaw et al.,
2005
12q14.1 K(C12), K41,
K119, ERVK-21
12 (-) 58721242 58730698 Human
Specific
< 2 SoloLTR gag, pol, env Costas et al.,
2001
12q24.11   12 (+) 111007843 111009325 Human
Specific
N/A    Medstrand and
Mager, 1998
16p11.2   16 (+) 34231474 34234142 Unknownd N/A    This Study
19p13.3 ERVK-22 19 (+) 385095 387637 Orangutanc N/A    This Study
19p12a K52 19 (+) 20387400 20397512 Orangutanc 29.71-53.79*    Hughes and
Coffin, 2001
19p12b K113 19 (-) 21841536 21841542 Human
Specific
< 2 Provirus gag, pol, env Turner et al.,
2001
19p12c K51 19 (+) 22757824 22764561 Orangutanc 12.96-23.47*    Hughes and
Coffin, 2001
19q11 K(C19), ERVK-
19
19 (-) 28128498 28137361 Human
Specific
N/A Internal
Polymorphis
m
gag, env Tonjes et al.,
1999
19q13.12a   19 (-) 36063207 36067434 Orangutan N/A    This Study
19q13.12b K(OLDAC012309),
KOLD12309
19 (-) 37597549 37607066 Gibbonc 22.87-41.42*    Reus et al.,
2001
19q13.42 LTR13 19 (+) 53862348 53868044 Orangutan N/A   env This Study
20q11.22 K(OLDAL136419),
K59
20 (+) 32714750 32724384 Rhesus 15.74-28.5    Hughes and
Coffin, 2001
21q21.1 K60, ERVK-23 21 (-) 19933916 19941962 Human
Specific
3.46-6.27    Kurdyukov et
al., 2001
22q11.21 K101, K(C22),
ERVK-24
22 (+) 18926187 18935307 Human
Specific
1.84-3.34    Barbulescu et
al., 1999
U219 K105 Unknown (+) 175210 176178 Gorillab 8.74-15.82 Provirus,
SoloLTR
  Barbulescu et
al., 1999
Yp11.2   Y (-) 6826441 6833384 Chimpanzee N/A    This Study
  1. aRefers to most distant species with shared provirus. Determined by searching for provirus at the corresponding locus by BLAT searching flanking
  2. sequence in the chimpanzee, orangutan, and rhesus publicly available genomes on the UCSC genome browser.
  3. bFrom Macfarlane and Simmons, 2004.
  4. cFrom Hughes and Coffin, 2001
  5. dProvirus flanking sequence does not have a non-human primate orthologous location.
  6. eProvirus is a product of a duplication event post-human/chimpanzee split.
  7. fAges based upon molecular clock calculations from Hughes and Coffin, 2005. N/A indicates unpaired LTRs or LTRs lacking sufficient sequence to determine age. Asterisk denotes age is listed for a recombinant provirus.