Cartoon schematic of HML-2 proviruses in the human genome. (A) A cartoon depicting the layout of the prototypical HML-2 retrovirus, including gag, pro, pol, and env gene positions. Splice sites of env, np9, and rec genes are also shown, with a faint gray band indicating the type 1 deletion region. Proviruses of the LTR5Hs (B), LTR5A (C), and LTR5B (D) groups are depicted and color-coded according to type. Type 1 proviruses colored in grey (with LTRs filled grey), type 2 colored in black (with LTRs filled black), and unclassified having open LTRs colored grey. Insertions and deletions < 3 bases are depicted with blue and red flags respectively. Larger insertions of retroelements are labeled according to type of element inserted, and large deletions are shown with dashed lines corresponding to missing sequence. Stop codons are indicated with a grey flag. Daggers indicate human-specific proviruses, with double daggers indicating polymorphic proviruses.