Skip to main content
Figure 2 | Retrovirology

Figure 2

From: HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Figure 2

Profiles of MVC resistance in primary peripheral blood mononuclear cells. Luciferase reporter viruses pseudotyped with MVC-Sens or MVC-Res Envs were used to infect PHA-activated, IL-2-stimulated PBMC in the presence of increasing concentrations of MVC as described in the Methods, and virus inhibition curves were generated and used to calculate the MPI as described previously [15]. The virus inhibition data are means of triplicates, and are derived from 3 independent experiments using cells from different donors. Error bars represent standard error. MPI, maximal percent inhibition; NDR, no dose response.

Back to article page