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Figure 8 | Retrovirology

Figure 8

From: Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses

Figure 8

The A120 mAb stimulates T cells and monocytes to produce β-chemokines in activated PBMCs. One day-activated PBMCs were depleted of CD19+B cells, CD4+T cells, CD8+T cells and/or CD14+monocytes using immunobeads conjugated with appropriate lineage specific mAbs, and then cultured in the presence of A120 mAb or isotype control mAb for one day. Concentrations of MIP-1α, MIP-1β and RANTES in the culture supernatants were assayed by ELISA. Representative data from three independent experiments are shown.

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