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Figure 6 | Retrovirology

Figure 6

From: Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses

Figure 6

Reversal of the A120 mAb-mediated inhibition of R5 HIV-1 infection in activated PBMCs with anti-CCR5 ligand-neutralizing mAbs. Activated PBMCs from 6 donors were infected with R5 HIV-1JR-FL and cultured in the presence of 10 μg/ml A120 mAb or isotype control mAb together or without anti-chemokine mAbs including anti-MIP-1α, anti-MIP-1β or anti-RANTES at 10 μg/ml for 4 days. Virus production in the culture supernatants was determined by p24 ELISA. The p24 levels were plotted as percent of control values obtained in cultures incubated in each anti-β-chemokine mAb for each donor.

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