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Figure 4 | Retrovirology

Figure 4

From: Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells

Figure 4

Representative immunohistochemistry showing expression of CCR5 by lamina propria lymphocytes in the small intestine of macaques vaccinated with attenuated SIV. Following vaccination of cynomolgus macaques (n = 20) with attenuated SIV immunohistochemical staining for CCR5+ cells was performed on sections of small intestine. At day 10 (left panel) a low frequency of CCR5+ cells (brown cell surface staining) was observed in the T cell areas of the lamina propria surrounding crypts (delineated by a dashed red line in each panel). In contrast, at day 125 (centre panel) a high frequency of CCR5+ cells was seen in the T cell areas of the lamina propria. The right hand panel shows a control slide with anti-CCR5 antibody omitted. Sections shown are from representative animals, counterstained with haematoxylin. Magnification is ×100.

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