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Figure 6 | Retrovirology

Figure 6

From: Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

Figure 6

HIV Env- and Gag-specific T cell responses after adenovirus-based vaccination. Two weeks after a single immunization with HIV Env and Gag encoding Ad5-based vectors in combination with Ad5 vectors encoding specific type I IFN subtypes, spleens were removed and after in vitro restimulation of spleen cells with HIV Gag-derived peptides the expression of IL-2, TNF-α and IFN-γ by CD4+ (A-C) and CD8+ T cells (D-F) was analyzed. The graphs show mean percentages with standard error of the means for six mice per group. Statistically significant differences (P < 0.05) compared to unvaccinated control mice (*) or mice vaccinated with Env- plus Gag-encoding vectors (#) are indicated. Data were acquired in two independent experiments.

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Retrovirology

ISSN: 1742-4690

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