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Table 5 Impact of PI resistance mutations on bevirimat resistance

From: HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Virus

Fold resistance

bevirimat

 

-

V362I

A364V

S368N

V370A

HXB2

-

2.8

> 150

6.6

> 150

PR-1 (20R-36I-54V-63P-71I-82T)

0.6

2.1

> 150

6.0

> 150

PR-2 (431V-10I-13V-36I-46I-54V-62V-63P-71T-82A-90M-93L)

2.1

> 150

> 150

> 150

> 150

  1. Levels of bevirimat resistance caused by single CA/p2 mutations in different protease backgrounds are given. Resistance is expressed as fold change in EC50 compared to HXB2. All numbers are averages of at least two separate experiments.