HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Table 4 Differences in mutations selected during the bevirimat in vitro selections

mutation	Wild-type proteases n (%)	PI resistant proteases n (%)	p-value
V362I	3/28 (10.7)	15/30 (50.0)	0.002
A364V	26/28 (92.9)	10/30 (33.3)	< 0.001
S368N	0/28 (0)	9/30 (30.0)	0.002
V370A	2/28 (7.1)	9/30 (30.0)	0.043
all QVT	2/28 (7.1)	12/30 (40.0)	0.005

The differences in mutations that were selected with viruses with either wild-type or PI resistant proteases during the bevirimat in vitro selections are listed. Absolute frequencies and the proportion of cultures harboring the mutations are given. P-values were determined using Fisher's exact test.

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