Retrovirology

Table 3 Mutations selected in viruses with PI resistant proteases during the bevirimat in vitro selections

From: HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

PI resistant proteases
	CA					p2
Gag position	359	360	361	362	363	364	365	366	367	368	369	370	371
HXB2 aa	K	A	R	V	L	A	E	A	M	S	Q	V	T
PR-1 n = 5	-	-	-	-	-	V	-	-	-	-	-	-	-
	-	-	-	-	-	A/V	-	-	-	-	-	-	-
	-	-	-	V/I	L/M	-	-	-	-	N	-	A	-
	-	-	-	V/I	-	-	-	-	-	S/N	-	-	T/N
	-	-	-	-	-	A/V	-	-	-	-	-	-	T/N
PR-2 n = 5	-	-	-	-	-	-	-	-	-	S/N	-	-	-
	-	-	-	-	-	-	-	-	-	-	-	V/A	-
	-	-	-	V/I	-	A/V	-	-	-	-	-	-	-
	-	-	-	V/I	-	-	-	-	-	-	-	-	-
	-	-	-	-	-	-	-	-	-	-	-	A	-
PR-3 n = 5	-	-	-	V/I	-	-	-	-	-	S/N	-	-	-
	-	-	-	-	-	A/V	-	-	-	-	-	-	-
	-	-	-	-	-	V	-	-	-	-	-	-	-
	-	-	-	-	-	-	-	-	-	S/N	-	V/A	-
	-	-	-	V/I	-	-	-	-	-	-	-	-	-
PR-4 n = 5	-	-	-	-	-	A/V	-	-	-	-	-	-	-
	-	-	-	V/I	-	-	-	-	-	-	-	V/A	-
	-	-	-	V/I	-	-	-	-	-	-	-	-	-
	-	-	-	V/I	-	-	-	-	-	S/N	-	-	-
	-	-	-	-	-	-	-	-	-	-	-	A	-
PR-5 n = 5	-	-	-	V/I	-	-	-	-	-	-	-	-	-
	-	-	-	-	L/M	A/V	-	-	-	-	-	-	-
	-	-	-	V/I	-	-	-	-	-	-	-	V/A	-
	-	-	-	-	-	-	-	-	-	-	-	V/L	-
	-	-	-	-	-	A/V	-	-	-	S/N	-	-	-
PR-6 n = 5	-	-	-	V/I	-	-	-	-	-	S/N	-	-	-
	-	-	-	V/I	-	A/V	-	-	-	S/N	-	-	-
	-	-	-	I	-	-	-	-	-	-	-	-	-
	-	-	-	V/I	-	-	-	-	-	-	-	V/A	-
	-	-	-	-	-	-	-	-	-	-	-	V/A	-

Schematic representation of the amino acid changes appearing in the CA/p2 region after bevirimat in vitro selection experiments with the PR-1 - PR-6 mutants. In vitro selections with the protease mutants were performed 5 times. Mutations that previously have been identified in vitro as bevirimat resistance mutations are indicated in bold. The QVT-polymorphisms that are associated with a reduced response to bevirimat in vivo are underlined. Previously unknown mutations are printed in italic type. The actual CA/p2 cleavage site is between amino acids 363 and 364.

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ISSN: 1742-4690

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