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Table 2 Mutations selected in viruses with wild-type proteases during the bevirimat in vitro selections

From: HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Wild-type proteases

 

CA

p2

Gag position

359

360

361

362

363

364

365

366

367

368

369

370

371

HXB2 aa

K

A

R

V

L

A

E

A

M

S

Q

V

T

WT

HXB2

n = 10

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

-

-

-

-

-

-

A

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

V/I

-

-

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

V/I

-

A/V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

WT

NL4-3

n = 10

-

-

-

-

-

A/V

-

A/V

-

-

-

-

-

 

-

-

-

-

-

A/V

-

-

-

-

-

V/A

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

A/V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

NC/p1

431V

n = 4

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

NC/p1

436E-437T

n = 4

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

V/I

-

A/V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

 

-

-

-

-

-

V

-

-

-

-

-

-

-

  1. Schematic representation of the amino acid changes appearing in the CA/p2 region during bevirimat in vitro selection experiments with wild-type HIV-1 or NC/p1 mutants. In vitro selections with wild-type viruses (HXB2 and NL4-3) were performed 10 times, the NC/p1 variants 5 times (n = 4 because one culture was discontinued for each virus). Mutations that previously have been identified in vitro as bevirimat resistance mutations are indicated in bold. The QVT-polymorphisms that are associated with a reduced response to bevirimat in vivo are underlined. The actual CA/p2 cleavage site is between amino acids 363 and 364.
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Retrovirology

ISSN: 1742-4690

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