From: Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase
Enzyme | IC50 (μM) | Fold Resistance |
---|---|---|
p66WT/p51WT | 0.52 ± 0.04 | - |
p66N348A/p51N348A | 1.77 ± 0.50 | 3.4 |
p66N348A/p51WT | 0.62 ± 0.07 | 1.2 |
p66N348I/p51N348I | 4.60 ± 0.45 | 8.6 |
p66N348I/p51WT | 0.50 ± 0.11 | 0.97 |
p66N348L/p51N348L | 5.93 ± 0.54 | 11.4 |
p66WT/p51N348L | 2.96 ± 0.10 | 5.7 |
p66N348Q/p51N348Q | 1.25 ± 0.13 | 2.4 |
p66N348Q/p51WT | 0.36 ± 0.05 | 0.7 |