Figure 3
From: Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase
AZT-MP excision activity of HIV-1 RT containing mutations at residue 348. A) Time course of ATP-mediated AZT-MP excision reactions carried out by HIV-1 RT containing mutations at residue N348 in both subunits of the enzyme on an RNA/DNA T/P. Data are the mean ± standard deviation from at least three independent experiments. B) Time course of ATP-mediated AZT-MP excision reactions carried out by HIV-1 RT containing mutations at residue N348 in only one subunit of the enzyme on an RNA/DNA T/P. Data are the mean ± standard deviation from at least three independent experiments. C) Time course of ATP-mediated AZT-MP excision reactions carried out by HIV-1 RT containing mutations at residue N348 in both subunits of the enzyme on a DNA/DNA T/P. Data are the average from at least two independent experiments.