Figure 4From: G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does notIn vitro RAL susceptibility of the HIV-2 reference (N1) and T1 and T3 resistant INs amplified form clinical isolates. Strand transfer reaction was carried using a 32P-labeled oligonucleotide mimicking the preprocessed substrate and 200 nM IN, in the presence of increasing concentrations of RAL at 37°C. Activity is expressed as a % of control without drug. Experiments were performed two times.Back to article page