Genotypic and functional properties of early infant HIV-1 envelopes

Retrovirology

Table 3 Genotypic analyses of V1-V5 sequences

Subject^a	V1-V5 length^b*	V1-V5 PNGS^c*	V3 charge	V3 glycan	V3 crown motif^d	Tropism^e
M1003	335	24 (23-25)	+3	Yes	APGR	R5
P1189	335	25 (25-25)	+3	Yes	APGR	R5
M1002	329 (329-333)	21 (20-24)	+3	Yes	GPGR	R5
P1031	329 (329-330)	19 (19-20)	+3	Yes	GPGR	R5
M1001	345 (342-347)	23 (22-25)	+2	Yes	GPGG, GPGR	R5
P1024	346 (345-346)	24 (23-24)	+2	Yes	GPGR	R5
M1007	328 (328-335)	23 (22-24)	+4	Yes	GPGR	R5
P1046	335	23 (21-23)	+4	Yes	GPGR	R5
M1006	332 (320-349)	24 (17-26)	+3 +4 +5	Yes, No	QPGR, QPGG	R5, R5/X4
P1049	332	24 (24-24)	+3	Yes	QPGR	R5

^aM, Mother; P, Infant.
^bMedian length of the env V1-V5 region as median (min-max).
^cMedian number of potential N-linked glycosylation sites in the V1-V5 region as median (min-max).
^dDominant variant presented first.
^eTropism determined in-vitro. R5, CCR5; R5/X4, CCR5/CXCR4.
*p > 0.05. Pairwise differences between maternal and infant values were evaluated using Mixed Model ANOVA with mother-infant pairs included as random effects.

ISSN: 1742-4690