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Table 1 Viruses and other immunogens studied in the new generation of humanized mice

From: The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

Infecting Agent

Humanized mouse model

References

Viruses:

  

HIV-1

Rag2-/-γc-/-

[44, 46, 4851, 5561, 6365]

HIV-1

NOD/SCIDγc-/- (hNOG)

[43, 66, 67, 72, 73]

HIV-1

NOD/SCIDγc-/- (hNSG)

[6871, 7476]

HIV-1

NOD/SCID BLT

[42, 45, 7779]

HIV-1

NOD/SCIDγc-/- (hNSG) BLT

[42, 81]

HIV-1

Rag1-/-γc-/-

[23]

HTLV

NOD/SCID

[25]

EBV

Rag2-/-γc-/-

[17, 122]

EBV

NOD/SCIDγc-/- (hNOG)

[27, 28]

EBV

NOD/SCIDγc-/- (hNSG)

[29]

EBV

NOD/SCID BLT

[30]

EBV

NOD/SCID

[26]

KSHV

NOD/SCID

[31, 32]

Dengue Virus

Rag2-/-γc-/-

[35]

Dengue Virus

NOD/SCID

[36]

HSV-2

Rag2-/-γc-/-

[34]

rAd-HCV

NOD/SCIDγc-/- (hNSG)

[37]

hCMV

NOD/SCIDγc-/- (hNSG)

[33]

HCV

Rag2-/-γc-/-Fah-/-

[40]

HBV

Rag2-/-γc-/-Fah-/-

[40]

HBV

Rag2-/-γc-/-uPa-/-

[123]

Bacteria:

  

Salmonella typhi

Rag2-/-γc-/-

[124]

Non-infectious agents:

  

Tetanus toxoid

Rag2-/-γc-/-

[17, 97]

Haemophilus influenza B conjugate vaccine

Rag2-/-γc-/-

[46]

Hepatitis B surface antigen vaccine

Rag2-/-γc-/-

[97]

Toxic shock syndrome toxin 1

NOD/SCID BLT

[30]

2,4-dinitrophenyl hapten-keyhole limpet hemocyanin

NOD/SCID BLT

[47]