Table 1 Proteins identified by mass spectrometry.
Gene ID | Proposed function(s) | Entrez n. & Ref. |
|---|---|---|
BAT1 | RNA helicase (UAP56) also involved in RNA export | 7919 |
FUS | Oncogene TLS (Translocated in liposarcoma protein) is a multifunctional RNA-binding protein factor | 2521 |
HNRPA3 | heterogeneous nuclear ribonucleoprotein | 220988 |
HNRPDP | heterogeneous nuclear ribonucleoprotein (hnRNP D0) | 8252 |
HNRPF | heterogeneous nuclear ribonucleoprotein | 3185 |
HNRPM | heterogeneous nuclear ribonucleoprotein | 4670 |
HNRPR | heterogeneous nuclear ribonucleoprotein | 10236 |
VIM | Vimentin, structural constituent of cytoskeleton | 7431 |
Other pre-mRNA/mRNA associated proteins | ||
BAT2 | May play a role in the regulation of pre-mRNA splicing | 7916 [48] |
C14orf166 | hCLE/CGI-99 is a mRNA transcription modulator | 51637[77] |
CAPRIN1 | GPI-anchored membrane protein 1/p137 associates with human pre-mRNA cleavage factor IIm | |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase, also shown to bind ssDNA/RNA and to have a role in RNAPII histone genes activation | |
Involved in HIV RNA binding/regulation | ||
DBPA | YB-1 interacts with TAR and Tat (*) | 8531 [50] |
DDX3X | Involved in Rev-mediated non-terminally spliced RNA export (*) | 1654 [10] |
EEF1A1 | Involved in RNA-dependent binding of Gag | 1915 [81] |
ILF3 | NF90 binds HIV-1 TAR and RRE (*) | |
MOV10 | RNA helicase that inhibits HIV-1 replication | |
PTBP1 | PTB has been involved in nuclear retention of multi-spliced HIV mRNAs in the nucleus of resting T cells (*) | 5725 [82] |
TUBA1B | HIV-1 Tat binds tubulin (*) | 10376 [83] |
RPL3 | Also described as HIV-1 TAR RNA-binding protein B (TARBP-b) | 6122 [84] |
SFPQ | PSF is involved in Rev-mediated export of HIV-1 RNA (*) | 6421 [53] |
UPF1 | Upframeshif protein 1 RNA helicase. Part of a post-splicing multiprotein complex. | |
Other | ||
CFL1 | It is the major component of nuclear and cytoplasmic actin rods. | 1072 |
EIF4A1 | ATP-dependent RNA helicase; eIF4F complex subunit involved in cap recognition and is required for mRNA binding to ribosome. | 1973 |
HIST1H1A | histone 1, H1a | 3024 |
H1FX | histone 1 family, H1 member X | 8971 |
PRKDC | DNA-dependent protein kinase (DNA-PKcs) involved in dsDNA break repair | 5591 |
RIF1 | Associated with aberrant telomers and dsDNA breaks | 55183 |
SCYL2 | Putative kinase in yeast | 55681 |
SPIN1 | Spindlin 1 belongs to the SPIN/STSY family | 10927 |