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Table 1 Proteins identified by mass spectrometry.

From: Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function

Gene ID Proposed function(s) Entrez n. & Ref.
Pre mRNA/mRNA binding proteins [41, 46, 47]
BAT1 RNA helicase (UAP56) also involved in RNA export 7919
FUS Oncogene TLS (Translocated in liposarcoma protein) is a multifunctional RNA-binding protein factor 2521
HNRPA3 heterogeneous nuclear ribonucleoprotein 220988
HNRPDP heterogeneous nuclear ribonucleoprotein (hnRNP D0) 8252
HNRPF heterogeneous nuclear ribonucleoprotein 3185
HNRPM heterogeneous nuclear ribonucleoprotein 4670
HNRPR heterogeneous nuclear ribonucleoprotein 10236
VIM Vimentin, structural constituent of cytoskeleton 7431
Other pre-mRNA/mRNA associated proteins
BAT2 May play a role in the regulation of pre-mRNA splicing 7916 [48]
C14orf166 hCLE/CGI-99 is a mRNA transcription modulator 51637[77]
CAPRIN1 GPI-anchored membrane protein 1/p137 associates with human pre-mRNA cleavage factor IIm 4076 [49, 78]
GAPDH Glyceraldehyde-3-phosphate dehydrogenase, also shown to bind ssDNA/RNA and to have a role in RNAPII histone genes activation 2597 [79, 80]
Involved in HIV RNA binding/regulation
DBPA YB-1 interacts with TAR and Tat (*) 8531 [50]
DDX3X Involved in Rev-mediated non-terminally spliced RNA export (*) 1654 [10]
EEF1A1 Involved in RNA-dependent binding of Gag 1915 [81]
ILF3 NF90 binds HIV-1 TAR and RRE (*) 3609 [51, 52]
MOV10 RNA helicase that inhibits HIV-1 replication 4343 [55, 56]
PTBP1 PTB has been involved in nuclear retention of multi-spliced HIV mRNAs in the nucleus of resting T cells (*) 5725 [82]
TUBA1B HIV-1 Tat binds tubulin (*) 10376 [83]
RPL3 Also described as HIV-1 TAR RNA-binding protein B (TARBP-b) 6122 [84]
SFPQ PSF is involved in Rev-mediated export of HIV-1 RNA (*) 6421 [53]
UPF1 Upframeshif protein 1 RNA helicase. Part of a post-splicing multiprotein complex. 5976 [54, 85]
CFL1 It is the major component of nuclear and cytoplasmic actin rods. 1072
EIF4A1 ATP-dependent RNA helicase; eIF4F complex subunit involved in cap recognition and is required for mRNA binding to ribosome. 1973
HIST1H1A histone 1, H1a 3024
H1FX histone 1 family, H1 member X 8971
PRKDC DNA-dependent protein kinase (DNA-PKcs) involved in dsDNA break repair 5591
RIF1 Associated with aberrant telomers and dsDNA breaks 55183
SCYL2 Putative kinase in yeast 55681
SPIN1 Spindlin 1 belongs to the SPIN/STSY family 10927
  1. (*) also identified as pre-mRNA/mRNA binding proteins [41, 46, 47].