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Table 1 Genotypic prediction of HIV-1 subtype D tropism compared to the TTT phenotypic assay

From: Genotypic prediction of HIV-1 subtype D tropism

   TTT Concordance Genotypic Prediction
Genotypic tool   R5 R5X4/X4   Sena Speb
Geno2pheno10 R5 12 1 58% 75% 54%
  X4 10 3 κ = 0.15 (p = 0.14)   
Combined 11/25 and net charge rules R5 15 0 73% 100% 68%
  X4 7 4 κ = 0.40 (p < 0.01)   
  1. aSen: sensitivity is the capacity for detecting CXCR4-using viruses, calculated by the number of concordant X4/R5X4 results divided by the number of viruses phenotyped as R5X4/X4.
  2. bSpe: specificity is the capacity for detecting exclusive CCR5-using viruses, calculated by the number of concordant R5 results divided by the number of viruses phenotyped as R5.
  3. κ: kappa coefficient.