From: SAMHD1: a new insight into HIV-1 restriction in myeloid cells
Lentiviruses | HIV-1 | SIVsm/HIV-2 # |
---|---|---|
Vpx protein expression | No | Yes |
Human SAMHD1 degradation | No | Yes |
Efficient infection of myeloid cells | No | Yes |
Triggering myeloid-cell-mediated innate anti-viral immunity through type I interferon | No | Yes |
Potential disease outcome | Spread of infection and AIDS | Confined infection, no AIDS in natural hosts |