Skip to main content

Table 1 Comparison of HIV-1 and HIV-2 regarding SAMHD1 degradation and potential disease consequences.

From: SAMHD1: a new insight into HIV-1 restriction in myeloid cells

Lentiviruses

HIV-1

SIVsm/HIV-2 #

Vpx protein expression

No

Yes

Human SAMHD1 degradation

No

Yes

Efficient infection of myeloid cells

No

Yes

Triggering myeloid-cell-mediated innate anti-viral immunity through type I interferon

No

Yes

Potential disease outcome

Spread of infection and AIDS

Confined infection, no AIDS in natural hosts

  1. # It is known that cross-species transmission of sooty mangabey SIV (SIVsm) to humans has given rise to HIV-2 [6].