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Table 1 Comparison of HIV-1 and HIV-2 regarding SAMHD1 degradation and potential disease consequences.

From: SAMHD1: a new insight into HIV-1 restriction in myeloid cells

Lentiviruses HIV-1 SIVsm/HIV-2 #
Vpx protein expression No Yes
Human SAMHD1 degradation No Yes
Efficient infection of myeloid cells No Yes
Triggering myeloid-cell-mediated innate anti-viral immunity through type I interferon No Yes
Potential disease outcome Spread of infection and AIDS Confined infection, no AIDS in natural hosts
  1. # It is known that cross-species transmission of sooty mangabey SIV (SIVsm) to humans has given rise to HIV-2 [6].