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Figure 4 | Retrovirology

Figure 4

From: Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

Figure 4

Repositioning of the V5 loop is associated with structural alterations in the CD4bs cavity. The gp120 models of CB3sc2 and Macs1br3 Envs (grey and blue ribbon representation, respectively) were superimposed, and their molecular surfaces were presented as blue or grey wire mesh (A). The consensus V1V2 stem (B) and V5 loop sequence (C) was deduced for all 81 primary Envs, and the degree of conservation at each amino acid position was calculated. The GAG linker sequence, which replaced the V1V2 loops in the crystal and model structures, is shown and highlighted as a grey box in panel (B).

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