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Figure 8 | Retrovirology

Figure 8

From: HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells

Figure 8

HIV-1 strains and gp120 inhibited the protein expression of some specific differentiation markers on MSCs differentiated towards the endothelial lineage. MSCs were differentiated to endothelial cells by VEGF treatment and at day 7 the cell cultures were collected and flow cytometry analysis of vWF, Flt-1 and KDR protein showed an inhibition of these three markers in MSC samples challenged with HIV-1 or gp120. In the histograms, shadowed areas represent the isotype irrelevant FITC-labeled mAb treated samples, the unshadowed areas represent VEGF treated sample challenged with HIV-1 or gp120 with or without neutralizing anti-gp120 pAb. A typical experiment is shown.

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