Skip to main content

Table 1 Summary of the Functional Properties of HIV-1 Env Mutants

From: Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

Env

Mutants

Cell-Cell

Fusion

(%)

Surface

Expression

(mAb 902)

(%)

Infectivity

(pseudotyped)

(%)

Virus-cell

Fusion

(%)

gp41

Incorporation

(%)

WT

100

100

100

100

100

A

62

101

57

17

101

B

41

195

16

0

8

C

30

125

13

0

5

D

31

120

4

17

9

E

30

136

1

0

22

Y

96

447

47

0

73

YA

62

563

6

14

154

YB

35

396

6

0

39

YC

30

563

5

0

56

YD

29

495

2

0

9

YE

17

194

1

0

17