Figure 1From: Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivityHIV-1 Env cytoplasmic domain Y- and LL-motif mutagenesis strategy. The key amino acids of the Y- and LL-motifs targeted for mutagenesis are listed under the corresponding location in the sequence of NL4-3 envelope cytoplasmic domain. WT residues are indicated by regular-faced type, and the residues in bold-faced type represent the mutations for each mutant. The glycoproteins are separated by those containing the WT Y712 motif and by those containing the Y712C mutation.Back to article page