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Table 7 Cellular miRNAs with published effect on HIV-1 exhibited similar expression trends between indicated infections of CEMx174 lymphocytes

From: Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1

Expression Level for

Indicated Infection State Relative to Mock a

 

miRNA

HIV-1

RSS

ΔVV

Targeted Transcript

and Expected Outcome

hsa-miR-17-5p

0.5

0.3

0.4

3'-UTR PCAF

(Triboulet 2007 [15])

hsa-miR-20a

0.6

0.2

0.5

Upregulation of cofactor

for Tat transcriptional

trans-activation, PCAF

hsa-miR-150

2.1

2.7

1. 8

 

hsa-miR-382

1.7

1.1

1.4

HIV-1 3'-UTR

hsa-miR-125b

0.2

0.3

0.2

(Huang 2007 [16])

Promotion of viral latency

hsa-miR-28

<MD

<MD

<MD

in resting T cells

hsa-miR-223

<MD

<MD

<MD

 

hsa-miR-198 b

2.1

1.7

2.1

3'-UTR CCNT1

(Rice and Sung 2009 [62])

Downregulation of

cofactor for Tat

transcriptional trans-

activation, cyclin T1

  1. a Expression trends of indicated cellular miRNAs given for each viral strain relative to uninfected controls.
  2. b <MD: less than the minimum detectable signal.
  3. c Upregulation trend was validated by qRT-PCR on independent infections.