From: Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1
Expression Level for Indicated Infection State Relative to Mock a | Â | |||
---|---|---|---|---|
miRNA | HIV-1 | RSS | ΔVV | Targeted Transcript and Expected Outcome |
hsa-miR-17-5p | 0.5 | 0.3 | 0.4 | 3'-UTR PCAF (Triboulet 2007 [15]) |
hsa-miR-20a | 0.6 | 0.2 | 0.5 | Upregulation of cofactor for Tat transcriptional trans-activation, PCAF |
hsa-miR-150 | 2.1 | 2.7 | 1. 8 | Â |
hsa-miR-382 | 1.7 | 1.1 | 1.4 | HIV-1 3'-UTR |
hsa-miR-125b | 0.2 | 0.3 | 0.2 | (Huang 2007 [16]) Promotion of viral latency |
hsa-miR-28 | <MD | <MD | <MD | in resting T cells |
hsa-miR-223 | <MD | <MD | <MD | Â |
hsa-miR-198 b | 2.1 | 1.7 | 2.1 | 3'-UTR CCNT1 (Rice and Sung 2009 [62]) Downregulation of cofactor for Tat transcriptional trans- activation, cyclin T1 |