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Table 5 Downregulation of selected miRNAs is diminished by RSS mutation

From: Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1

  Downregulation Relative to Mock Infection a Lessened Downregulation for RSS Relative to Indicated Infection b
miRNA HIV-1 RSS ΔVV HIV-1 ΔVV
hsa-miR-10a 26% 43% 32% 17% 10%
hsa-miR-23a 19% 34% 22% 15% 11%
hsa-miR-25 27% 43% 15% 17% 28%
hsa-miR-27a 31% 37% 18% 6% 19%
hsa-miR-30d 34% 54% 30% 20% 25%
hsa-miR-32 11% 24% 4% 13% 19%
hsa-miR-92 33% 50% 33% 17% 17%
hsa-miR-95 39% 51% 41% 12% 10%
hsa-miR-99b 46% 53% 33% 7% 20%
hsa-miR-100 24% 35% 19% 11% 16%
hsa-miR-103 46% 53% 37% 6% 16%
hsa-miR-107 42% 51% 31% 8% 20%
hsa-miR-125b 16% 26% 19% 10% 7%
hsa-miR-128 26% 47% 29% 21% 19%
hsa-miR-135a 23% 35% 18% 12% 17%
hsa-miR-142-5p 24% 30% 20% 5% 10%
hsa-miR-148b 37% 49% 39% 12% 10%
hsa-miR-181a 40% 53% 47% 13% 6%
hsa-miR-186 50% 64% 50% 14% 14%
hsa-miR-193a 40% 69% 44% 29% 24%
hsa-miR-369-3p 27% 41% 39% 14% 2%
hsa-miR-376a 43% 59% 43% 16% 15%
hsa-miR-379 40% 61% 47% 21% 14%
hsa-miR-423 44% 65% 24% 21% 41%
hsa-miR-601 31% 38% 21% 7% 17%
hsa-miR-660 40% 66% 42% 26% 24%
hsa-miR-671 36% 47% 46% 11% 0
  1. a Expression trend compared to uninfected CEMx174 lymphocytes (Mock). Bold designates miRNAs downregulated in PBMC of HIV-1 patients [55].
  2. b Percentage increase between RSS relative to indicated strain.