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Table 1 Novel gp41 mutations significantly associated with gp120V3 mutations

From: Selected amino acid mutations in HIV-1 B subtype gp41 are Associated with Specific gp120V3signatures in the regulation of Co-Receptor usage

gp41 mutations

Frequency no. (%) of isolatesa

Frequency % in X4-tropic virusesb

Correlated mutations

Frequency no. (%) of isolatesa

Covariation frequency no. (%) of isolatesc

φ d

P e

A30T gp41

10 (5.1)

100

F20IVY v3

34 (17.3)

8 (80.0)

0.38

0.001

   

E25KQR v3

62 (31.6)

9 (90.0)

0.29

0.006

   

S11S v3

109 (55.6)

0 (0)

-0.26

0.009

L34M gp41

5 (2.5)

100

N7KTY v3

15 (7.6)

3 (60.0)

0.32

0.055

A96N gp41

27 (13.8)

29.6

T22A v3

113 (57.6)

23 (85.2)

0.22

0.03

   

S11KR v3

51 (26.0)

3 (11.1)

-0.17

0.018

A96T gp41

51 (26.0)

72.5

N140IT gp41

22 (11.2)

12 (23.5)

0.23

0.054

   

T22A v3

113 (57.6)

19 (37.2)

-0.24

0.022

S129DQ gp41

43 (20.9)

26.8

S11KR v3

51 (26.0)

4 (9.8)

-0.21

0.041

S129N gp41

24 (12.2)

75

I12MV v3

19 (9.7)

7 (29.2)

0.26

0.041

N140IT gp41

22 (11.2)

86.4

N7KTY v3

15 (7.6)

6 (27.3)

0.26

0.046

   

A96T gp41

51 (26.0)

12 (54.5)

0.23

0.054

   

S11S v3

109 (55.6)

5 (22.7)

-0.24

0.028

A189S gp41

13 (6.6)

92.3

Q32KR v3

50 (25.5)

9 (69.2)

0.27

0.021

N195K gp41

6 (3.1)

100

T8I v3

8 (4.1)

3 (50.0)

0.41

0.022

   

S11KR v3

51 (26.0)

6 (100)

0.16

0.041

L210P gp41

12 (6.1)

83.3

G24EKR v3

23 (11.7)

6 (50.0)

0.31

0.019

  1. a Frequency was determined in 196 isolates from HIV-1 infected patients having FPR < 5% and FPR > 70%, using the Geno2Pheno algorithm.
  2. b Frequency was determined in 105 HIV-1 isolates reported as X4-tropic at genotypic test (FPR < 5%).
  3. c Percentages were calculated in patients with each specific gp41 mutation.
  4. d Positive and negative correlations with φ > 0.15 and φ < -0.15, respectively, are shown.
  5. e P values significant (P ≤ 0.05) after correction for multiple hypothesis testing [65].