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Table 4 NVP susceptibilities associated with RT domains of patient P66.

From: The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

Virus

IC50a

FCb

Wild-type

86.47 ± 11.84

 

4-RT

>6,000

>66

4-Pol

>6,000

>66

4-Pol-Cn

>6,000

>66

4-Cn-Rh

410.5 ± 55.2

4.7

17-RT

>6,000

>66

17-Pol

>6,000

>66

17-Pol-Cn

>6,000

>66

17-Cn-Rh

73.83 ± 8.54

0.9

37-RT

>6,000

>66

37-Pol

>6,000

>66

37-Pol-Cn

>6,000

>66

37-Cn-Rh

88.23 ± 12.95

1.0

  1. a50% inhibitory concentration in nM ± SEM.
  2. b Fold change in IC50 compared to wild-type virus.