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Table 3 3TC, AZT and FTC susceptibilities associated with RT domains of patient P66.

From: The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

Virus

3TC

AZT

FTC

 

IC50a

FCb

IC50a

FCb

IC50a

FCb

Wild-type

8.5 ± 0.8

 

168.6 ± 46.8

 

2.2 ± 0.3

 

4-RT

198.8 ± 18.6

23.3

76.9 ± 6.8

0.5

184.2 ± 14.2

84.9

4-Pol

211.5 ± 17.5

24.8

60.0 ± 13.8

0.4

168.1 ± 6.4

77.5

17-RT

224.1 ± 16.9

26.3

56.4 ± 7.2

0.3

228.8 ± 6.7

105.5

17-Pol

206.5 ± 9.7

24.2

58.1 ± 14.2

0.3

218.9 ± 13.3

100.9

37-RT

219.7 ± 7.5

25.8

5120.9 ± 515.6

30.4

230.9 ± 10.2

106.4

37-Pol

217.8 ± 18.1

25.6

2025.3 ± 144.2

12.0

231.5 ± 17.1

106.7

  1. a50% inhibitory concentration in nM ± SEM.
  2. bFold change in IC50 compared to wild-type virus.