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Figure 2 | Retrovirology

Figure 2

From: The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

Figure 2

ML phylogenetic analysis of single genome sequences. Branch lengths were estimated using the GTR model of substitution and are drawn in scale with the bar at the bottom representing 0.008 nucleotide substitutions per site. The colour of each tip branch represents the time after initiation of therapy when the sample from which the single-genome originates was collected as shown in the legend in each figure. (A) Phylogenetic tree of 70 single genomes generated from 3 sequential samples from patient P66 infected with subtype C HIV-1 virus. (B) Same as (A) but with the following 12 RT drug resistance codons removed from the aligned single-genome sequences to determine the effect of drug resistance mutations on viral evolution: 62, 69, 75, 90, 138, 151, 181, 184, 210, 221, 230 and 348. The trees were rooted using the subtype C reference sequence MJ4.

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Retrovirology

ISSN: 1742-4690

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