TY - JOUR AU - Zhang, Hongtao AU - Curreli, Francesca AU - Zhang, Xihui AU - Bhattacharya, Shibani AU - Waheed, Abdul A. AU - Cooper, Alan AU - Cowburn, David AU - Freed, Eric O. AU - Debnath, Asim K. PY - 2011 DA - 2011/05/03 TI - Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain JO - Retrovirology SP - 28 VL - 8 IS - 1 AB - The C-terminal domain (CTD) of HIV-1 capsid (CA), like full-length CA, forms dimers in solution and CTD dimerization is a major driving force in Gag assembly and maturation. Mutations of the residues at the CTD dimer interface impair virus assembly and render the virus non-infectious. Therefore, the CTD represents a potential target for designing anti-HIV-1 drugs. SN - 1742-4690 UR - https://doi.org/10.1186/1742-4690-8-28 DO - 10.1186/1742-4690-8-28 ID - Zhang2011 ER -