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Table 1 Animals and assays performed

From: Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues

Animal SIVmac
strain
Route of
infection
Period of
investigation1
Average plasma viral
RNA load
FACS CM9 ELISpot ELISA ICS Viral RNA
load
Proviral
load
           D C B D C B P
   Controllers                
2139* 239 tonsillar 63-245 1.1 × 102 X X X X X X X X X X X X
2151* 239 tonsillar 63-245 8.4 × 101 X X X X X X X X X X X X
2153* 239 tonsillar 64-245 1.2 × 102 X X X X X X X X X X X X
2155* 239 tonsillar 63-245 1.1 × 102 X X X X X X X X X X X X
2172 239 tonsillar 68-245 2.5 × 102 X X X X X X X X X X X X
2191* 239 tonsillar 71-146 3.8 × 103 X X   X X        
8644* 251 tonsillar 444-550 5.5 × 102 X    X X X X X X X X X
9045* 239 i.v. 490-507 1.8 × 104 X    X X        
9794 239 tonsillar 209-315 1.2 × 103 X    X X X X X X X X X
12533* 239 tonsillar 68-116 2.0 × 103 X X X X         
12535 239 tonsillar 71-153 1.3 × 102 X   X X X X X X     
12536*,2 239 tonsillar 67-157 4.3 × 102 X X X X X X X X     
12671* 239 tonsillar 68-241 9.9 × 101 X X X X X X X X X X X X
12672 239 tonsillar 71-241 1.7 × 102 X   X X X X X X X X X X
   Progressors
2118* 239 tonsillar 99-177 1.7 × 105 X X   X X    X    X X
2141 239 tonsillar 104-120 6.5 × 104 X   X          
2188* 239 tonsillar 107-124 3.1 × 105 X X X          
12537 239 tonsillar 102-107 7.5 × 105 X            
2168 239 tonsillar 112-116 1.1 × 105 X   X          
10425 239 tonsillar 113-116 3.7 × 104 X   X          
12539 239 tonsillar 116-117 3.2 × 105 X   X          
2192 251 i.v. 68-92 9.3 × 104 X   X X   X X      
12531 239 tonsillar 128-146 4.8 × 104 X   X X X X X      
12538* 251 i.v. 85-115 2.9 × 105 X    X X X X     X X
11139* 251 i.v. 69-121 1.1 × 105 X X X X X X X X    X X
13251* 251 i.v. 69-115 2.0 × 105 X X X X X X X X    X X
13258 251 i.v. 96-105 8.2 × 105    X X X X X X     
13250* 251 i.v. 105-115 1.1 × 105    X X X    X    X X
13257 251 i.v. 105-115 2.8 × 105    X X X    X     
13260 251 i.v. 92-101 1.2 × 105    X    X X X     
  1. *, animals expressing the MHC class I allele MamuA1*001
  2. 1, weeks post infection
  3. 2, this animal had an increasing viral load after week 160 post infection, but was separately analyzed until week 250 post infection
  4. FACS, flow cytometric phenotype staining; CM9, Gag-CM9 tetramer staining; D, duodenum; C, colon; B, BAL; P, PBMC; ICS, intracellular cytokine staining