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Table 1 Animals and assays performed

From: Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues

Animal

SIVmac

strain

Route of

infection

Period of

investigation1

Average plasma viral

RNA load

FACS

CM9

ELISpot

ELISA

ICS

Viral RNA

load

Proviral

load

          

D

C

B

D

C

B

P

   Controllers

               

2139*

239

tonsillar

63-245

1.1 × 102

X

X

X

X

X

X

X

X

X

X

X

X

2151*

239

tonsillar

63-245

8.4 × 101

X

X

X

X

X

X

X

X

X

X

X

X

2153*

239

tonsillar

64-245

1.2 × 102

X

X

X

X

X

X

X

X

X

X

X

X

2155*

239

tonsillar

63-245

1.1 × 102

X

X

X

X

X

X

X

X

X

X

X

X

2172

239

tonsillar

68-245

2.5 × 102

X

X

X

X

X

X

X

X

X

X

X

X

2191*

239

tonsillar

71-146

3.8 × 103

X

X

 

X

X

       

8644*

251

tonsillar

444-550

5.5 × 102

X

  

X

X

X

X

X

X

X

X

X

9045*

239

i.v.

490-507

1.8 × 104

X

  

X

X

       

9794

239

tonsillar

209-315

1.2 × 103

X

  

X

X

X

X

X

X

X

X

X

12533*

239

tonsillar

68-116

2.0 × 103

X

X

X

X

        

12535

239

tonsillar

71-153

1.3 × 102

X

 

X

X

X

X

X

X

    

12536*,2

239

tonsillar

67-157

4.3 × 102

X

X

X

X

X

X

X

X

    

12671*

239

tonsillar

68-241

9.9 × 101

X

X

X

X

X

X

X

X

X

X

X

X

12672

239

tonsillar

71-241

1.7 × 102

X

 

X

X

X

X

X

X

X

X

X

X

   Progressors

2118*

239

tonsillar

99-177

1.7 × 105

X

X

 

X

X

  

X

  

X

X

2141

239

tonsillar

104-120

6.5 × 104

X

 

X

         

2188*

239

tonsillar

107-124

3.1 × 105

X

X

X

         

12537

239

tonsillar

102-107

7.5 × 105

X

           

2168

239

tonsillar

112-116

1.1 × 105

X

 

X

         

10425

239

tonsillar

113-116

3.7 × 104

X

 

X

         

12539

239

tonsillar

116-117

3.2 × 105

X

 

X

         

2192

251

i.v.

68-92

9.3 × 104

X

 

X

X

 

X

X

     

12531

239

tonsillar

128-146

4.8 × 104

X

 

X

X

X

X

X

     

12538*

251

i.v.

85-115

2.9 × 105

X

  

X

X

X

X

   

X

X

11139*

251

i.v.

69-121

1.1 × 105

X

X

X

X

X

X

X

X

  

X

X

13251*

251

i.v.

69-115

2.0 × 105

X

X

X

X

X

X

X

X

  

X

X

13258

251

i.v.

96-105

8.2 × 105

  

X

X

X

X

X

X

    

13250*

251

i.v.

105-115

1.1 × 105

  

X

X

X

  

X

  

X

X

13257

251

i.v.

105-115

2.8 × 105

  

X

X

X

  

X

    

13260

251

i.v.

92-101

1.2 × 105

  

X

  

X

X

X

    
  1. *, animals expressing the MHC class I allele MamuA1*001
  2. 1, weeks post infection
  3. 2, this animal had an increasing viral load after week 160 post infection, but was separately analyzed until week 250 post infection
  4. FACS, flow cytometric phenotype staining; CM9, Gag-CM9 tetramer staining; D, duodenum; C, colon; B, BAL; P, PBMC; ICS, intracellular cytokine staining
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Retrovirology

ISSN: 1742-4690

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