Virus-specific cytokine response of PBMC and BAL memory T-cells from controllers and progressors. Percentage of polyfunctional cells and total cytokine secreting cells after SIV-Gag stimulation in the CD4+ memory T-cell subset of PBMC (A) and BAL (B) and in the CD8+ memory T-cell subset of PBMC (C) and BAL (D) in controllers, progressors and uninfected animals. The right panels show the total cytokine response of CD8+ memory T-cells in PBMC (E) and BAL cells (F) of Mamu-A1*001 positive controllers and progressors after stimulation with the CM9-peptide only. For definition of polyfunctional cells and the total response see figure legend 5. Horizontal lines represent the mean of each group and P-values were calculated with the Mann-Whitney's U-test (*P < 0.05, **P < 0.01 and ***P < 0.001).