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Figure 5 | Retrovirology

Figure 5

From: Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues

Figure 5

Cytokine response in PBMC and BAL of controllers, progressors and uninfected animals after polyclonal stimulation. Percentage of polyfunctional cells and total cytokine secreting cells after SEB stimulation in the CD4+ memory T-cell subset of PBMC (A) and BAL (B) as well as in the CD8+ memory T-cell subset of PBMC (C) and BAL (D) in controllers, progressors and uninfected animals. Polyfunctional cells were defined as expressing two or three cytokines (IFN-γ+ TNF-α+, IFN-γ+ IL-2+, TNF-α+ IL-2+, IFN-γ+ TNF-α+ IL-2+) and the total response comprises polyfunctional cells and cells secreting one cytokine only (single positive cells). Horizontal lines represent the mean of each group and P-values were calculated with the Mann-Whitney's U-test (*P < 0.05 and **P < 0.01).

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